3 edition of Brain G-proteins in drug dependence found in the catalog.
Brain G-proteins in drug dependence
Thesis (M.Sc.) -- University of Toronto, 1999.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative. --|
G Proteins is an introduction to one class of systems used for signal transduction at the cell surface, with emphasis on its utilization of a heterotrimeric GTP-binding protein (G protein) to mediate the transfer of information across the plasma membrane, from receptor to Edition: 2. Alcohol is the most abused drug the United States, the apparent per capita consumption of ethanol from all alcoholic beverage types combined was gallons pure ethanol in In , million Americans aged >or=to 12 yr had used alcohol in the last month (51% of the population).
This chapter reviews the studies which provide evidence for a synergistic effect of drugs of abuse and human immunodeficiency virus (HIV) infection on brain function. Understanding the interactive mechanisms of this neurodegeneration is critical to our ability to optimize therapy for drug-abusing HIV-infected populations. The chapter discusses the proposed underlying mechanisms of this Author: Jeffrey A. Rumbaugh, Avindra Nath. Full text of "Problems of drug dependence, proceedings of the 62nd Annual Scientific Meeting, the College on Problems of Drug Dependence, Inc." See other formats.
f5a-arh Actions of the brain’s γ-aminobutyric acid (GABA) system. GABA acts in part through GABAA receptors, which serve as ion channels for chloride ions (Cl−). Greater influx of Cl− into the neuron makes it more difficult for the cell to generate a new nerve impulse. G proteins come in many shapes and sizes. Most are used for cell signaling, but other types play an important role in other tasks, such as powering protein synthesis. The ones described here are termed heterotrimeric G proteins because they are composed of three different chains, denoted as alpha (tan), beta (blue), and gamma (green).
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Substance dependence, also known as drug dependence, is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use.
A drug addiction, a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences.
An addictive drug is a drug which is both rewarding and lty: Psychiatry. Addiction and dependence glossary; addiction – a brain disorder characterized by compulsive engagement in rewarding stimuli despite adverse consequences; addictive behavior – a behavior that is both rewarding and reinforcing; addictive drug – a drug that is both rewarding and reinforcing; dependence – an adaptive state associated with a withdrawal syndrome upon cessation of repeated Specialty: Psychiatry.
Norepinephrine, particularly in the forebrain, is released in the brain during stressful events and plays an important role in the anxiety/stress-like responses associated with drug dependence. Noradrenergic projections from the locus coeruleus play a key role in maintaining attentional homeostasis (regulating arousal/attention setpoint).
Research should be supported in the following areas: developing better animal models of the motivational aspects of drug dependence (with particular emphasis on protracted abstinence and propensity to relapse); genetics research; brain imaging; the neurobiology of co-occurring psychiatric disorders and drug abuse; animal models of the effects.
activity of G-proteins and the CAMP second messenger and protein phosphorylation pathway mediate important aspects of opiate, and possibly cocaine, addiction in a number of drug- responsive brain regions.
Molecular mechanisms underlying opiate tolerance, dependence, and withdrawal: studies in Cited by: Brain Power: Why Proteins Are Smart The brain's protein connection: How proteins keep the mind working smoothly, and properly.
By Willow Lawson, published January 3. Activation of G-proteins in brain by endogenous and exogenous cannabinoids Steven R. Childers Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston-Salem, NCCited by: Glutamate is the primary excitatory amino acid transmitter in the brain and acts on various ionotropic and metabotropic receptor subtypes.
Specific subtypes of glutamate receptors are not only molecular targets for some drugs of abuse, but also mediate many of the maladaptive neuroadaptations that occur as a result of chronic drug : M.
Foster Olive. Drug addiction is marked by continued drug-seeking behavior despite deleterious consequences and a heightened propensity to relapse notwithstanding long, drug-free periods. The enduring nature of addiction has been hypothesized to arise from perturbations in intracellular signaling, gene expression, and brain circuitry induced by substance by: 8.
The book is composed of 44 chapters, all concerned with basic science research relevant to drug dependence. even for basic scientists this book is best approached as one where at most a few chapters may be of interest to any researcher in drug addiction." (Jason White, Drug And Alcohol Review, Vol.
28, July, ). The Effects of Drug Abuse on the Human Nervous System presents objective, state-of-the-art information on the impact of drug abuse on the human nervous system, with each chapter offering a specific focus on nicotine, alcohol, marijuana, cocaine, methamphetamine, MDMA, sedative-hypnotics, and designer drugs.
Other chapters provide a context for Author: Bertha Madras. O'Brien CP. Drug addiction and drug abuse. In: Hardman JG, Limbird L, eds.
Goodman and Gilman's The Pharmacologic Basis of Therapeutics. 9 th Edition. New York: McGraw-Hill. – Olds ME, Milner P.
Positive reinforcement produced by electrical stimulation of septal area and other regions of the rat brain. THE SCIENCE OF ADDICTION: DRUGS AND THE BRAIN Under each of the receptor "ghosts" is a small rectangle containing globules of chemicals known as G proteins.
These are the beginning of a chemical and electrical cascade of events that make neuron #2 more likely to fire (excitation) or less likely to fire (inhibition) and that carry the. Drug addiction is likely to affect all of our lives, with any luck not through our own actions but probably because of one or more of our family and friends.
Now firmly entrenched as a brain disease ([Leshner, ]; [Wise, ]), drug addiction is among the most costly such diseases inCited by: G protein ppt final 1. G-protein coupled receptors and drugs modulating them 2.
• General description of Receptors and signaling • G- Protein coupled receptor and its mechanism • Classes of GPCR • Second messenger and its applied pharmacology • Recent development • Tools for drug discovery • Conclusion Brief outline.
The course of drug dependence is presented as a continuum from no drug use via controlled use to an actual dependence on the drug. Specific brain opioid systems belonging to four conceptualized. Opioid drugs are a well-known class of drug due to both their ability to kill pain and kill people.
Watch part 1 of this two-part series to learn how opioid drugs can. Opioid dependence (OD), mainly characterized by persistent drug-taking and drug-seeking behavior, is a chronic brain disorder that has seriously negative social and health consequences .
Drug Dependence- physical dependence is the tolerance built up to the effects of a drug so that more and more of the drug become necessary to get the same effect, associated with withdrawal symptoms.
Psychological dependence is the conviction that one cannot get through the day without using. ISBN: OCLC Number: Description: xxiii, pages: illustrations: Contents: I.
General Topics DARPP Mediates the Actions of Multiple Drugs of Abuse Drug Discovery From Natural Sources Computational Methods in Drug Design: Modeling G Protein-Coupled Receptor Monomers, Dimers, and Oligomers.
Overview: Biological processes relevant to drugs of dependence Overview: Biological processes relevant to drugs of dependence GRUNBERG, NEIL E.
Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Jones Bridge Road, Bethesda, Maryland, USA Abstract Key points are highlighted from five papers that address biological.A form of treatment for drug dependence that involves giving gradually decreasing doses of the drug to prevent withdrawal symptoms, thereby weaning the patient from the drug of dependence.
Can be accomplished with any medication in the same category as the initial drug of dependence.The evidence that tolerance to opioid agonist actions and the development of dependence on opioid agonist after chronic exposure might also be related to modified interactions between receptor and G protein, and also to changes in the concentrations of individual Cited by: